Kimberly Verniers

Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells

The paper identifies NESPR, an adrenergic-specific lncRNA, as a regulator of neuroblastoma cell identity that prevents cell death by attenuating stress.

Intact messenger RNA exists in human blood plasma and urine, and their purified macromolecular compartments

This study identifies intact messenger RNA in human blood plasma and urine using long-read sequencing, showing differences and shared transcripts between biofluids and their macromolecular compartments.

Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

Blocking abundant RNA transcripts by high-affinity oligonucleotides during transcriptome library preparation

The paper introduces a method to block abundant RNA transcripts during library preparation, improving transcriptome coverage and complexity by reducing competition from highly abundant RNAs.

A 3'-end capture sequencing method for high-throughput targeted gene expression profiling

This paper introduces a 3'-end capture sequencing method for targeted gene expression profiling, achieving 100-fold enrichment of target genes with shallow sequencing.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

The paper evaluates RNA purification kits and blood collection tubes for exRNA quality, finding that preservation tubes and purification methods significantly affect RNA stability, sensitivity, and reproducibility.

Charting extracellular transcriptomes in The Human Biofluid RNA Atlas

The paper creates a comprehensive atlas of RNA transcriptomes across 20 human biofluids, revealing significant differences in RNA concentration and composition, and validates potential biomarkers in disease cohorts.

Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles

The paper evaluates the SMARTer Stranded Total RNA-Seq method's performance in quantifying total RNA from various human biofluids and extracellular vesicles, finding it accurate, precise, and capable of detecting thousands of genes.