Niels Vandamme

This study benchmarks multiple sequencing-based spatial transcriptomics platforms across tissue types and preservation methods to evaluate their performance and establish standardized metrics for future research.

The paper examines systemic immune changes across the CFTR dysfunction spectrum using single-cell immune profiling in pwCF, carriers, and non-carriers, revealing immune signatures linked to CFTR function.

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

The paper identifies S100A8-enriched microglia in tauopathy and accelerated aging mouse models, showing their presence in human AD and tauopathy biopsies.

The paper introduces a method to block abundant RNA transcripts during library preparation, improving transcriptome coverage and complexity by reducing competition from highly abundant RNAs.

This study compares antibody- and lipid-based hashing methods for single-cell RNA-seq, finding antibody-based hashing more efficient and cost-effective for clinical samples.

DALI is a software tool that integrates multimodal single-cell RNA-seq and immune receptor data to analyze T and B cell diversity, supporting both bioinformaticians and immunologists.

This study benchmarks single cell RNA-seq technologies to assess their ability to detect transcriptional changes in NGP neuroblastoma cells after nutlin-3 treatment, finding heterogeneity in response not captured by bulk RNA-seq.