Author

Lisa Depestel

Ghent UniversityORCID 0000-0001-5690-3258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ellen SandersiD· 2 shared Fanny De VloediD· 2 shared Frank SpelemaniD· 2 shared Iris H. NeleniD· 2 shared Kaat DurinckiD· 2 shared Alexander M.M. EggermontiD· 1 shared Angeline Praveena Enton Raj· 1 shared Anna A. SablinaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Ellen SandersORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyCell Death and DiseasePeer-reviewedFeb 25, 2026

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

Iris H. Nelen, Soetkin Leys, Sarah-Lee Bekaert…·Kaat Durinck

This study identifies synergistic effects of second-generation RRM2 and CHK1 inhibitors in neuroblastoma and sarcomas, showing enhanced replication stress and apoptosis.

3 citationstop 2%

humanbulk RNA-seq

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GeneticsbioRxivPreprintApr 7, 2025

Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells

Louis Delhaye, Dries Rombaut, Eric James de Bony…·Pieter Mestdagh

The paper identifies NESPR, an adrenergic-specific lncRNA, as a regulator of neuroblastoma cell identity that prevents cell death by attenuating stress.

1 citation

humanzebrafish

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Cancer BiologybioRxivPreprintAug 29, 2024

5UTR translational inhibition of neuroblastoma dependency factors using the CR-1-31-B rocaglate

C. Nunes, S.-L. Bekaert, S. Parsa…·Kaat Durinck

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.

DOI 10.1101/2024.08.29.610236

humanproteomics

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