Author

Uri R. Mbonye

Case Western Reserve UniversityORCID 0000-0002-7694-0803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Jonathan KarniD· 2 shared Amie DonneriD· 1 shared Ana BellomoiD· 1 shared Eleonora ElhalemiD· 1 shared Konstantin LeskoviD· 1 shared Lucía Gandolfi DonadioiD· 1 shared Maria Julieta CominiD· 1 shared Meenakshi Shukla· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Jonathan KarnORCID

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2 papers

Recent·Most cited

RasGRP1 agonists stimulate P-TEFb biogenesis via MEK-ERK-mTORC1 signaling to reverse HIV latency with minimal CD4 downregulation

Uri R. Mbonye, Ana Bellomo, Eleonora Elhalem, Lucía Gandolfi Donadio, Muda Yang, Amie Donner, Maria Julieta Comin, Jonathan Karn

bioRxiv · Jan 15, 2026 · PreprintCell Biology

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

Uri R. Mbonye, Konstantin Leskov, Meenakshi Shukla, Saba Valadkhan, Jonathan Karn

This study identifies PKC-independent signaling pathways that reactivate HIV latency by regulating P-TEFb availability in CD4+ T cells.

PLoS Pathogens · Sep 16, 2021Peer-reviewedMolecular Biology