This study identifies SLC25A34 as a fasting-inducible mitochondrial carrier that mediates PEP import, linking amino acid catabolism to muscle preservation during fasting.

Science Advances · Jul 31, 2026Peer-reviewedPhysiology

Mitochondrial control of glycerolipid synthesis by a PEP shuttle

Tadashi Yamamuro, Daisuke Katoh, Guilherme Martins Silva, Hiroshi Nishida, Satoshi Oikawa, Yusuke Higuchi, Dandan Wang, Masanori Fujimoto, Naofumi Yoshida, M. Li, Jihoon Shin, Zezhou Zhao, Jin-Seon Yook, Li Sun, Shingo Kajimura

This study identifies SLC25A35 as a mitochondrial PEP transporter that regulates glycerolipid synthesis in lipogenic cells, with implications for metabolic diseases.

Cell · Mar 17, 2026Peer-reviewedCell Biology

The Rubicon-WIPI axis regulates exosome biogenesis during aging

Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, Yoshio Kato, Ryuya Edahiro, Ryosuke Kawagoe, Takako Taniguchi, Yôko Tanaka, , Tamotsu Yoshimori

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

Nature Cell Biology · Aug 22, 2024Peer-reviewedCell Biology