An in silico framework for evaluating PRS-guided prognostic enrichment in clinical trial design
Ruoyi Cai, Joshua Gillard, Sherry Yang, Lindsay E. Clegg, Samvel B. Gasparyan, Ying Lü, Andrzej Nowojewski, Lü Tian, Ola Vedin, Euan Angus Ashley, Manuel A. Rivas, Jack William O’Sullivan
This paper develops an in silico framework to evaluate the impact of polygenic risk score (PRS)-guided prognostic enrichment on clinical trial design using genomic and electronic health record data.
medRxiv · Apr 21, 2026 · PreprintGenetic & Genomic Medicine