MICHAEL J. SEAGAR

The paper shows LGI1 binds gangliosides and may organize lipid platforms for ion channels, and its loss disrupts these platforms in mice.

The paper identifies a hyperglycosylated and phosphorylated form of Kv1.2 upregulated in Lgi1-/- mice and reports changes in its interactome.

This study investigates Kv1 channel downregulation in LGI1 knock-out mice, showing it occurs in somatodendritic regions and is linked to increased neuronal bursting and changes in the Kv1 interactome.

The paper uses patient-derived autoantibodies to study LGI1 localization and interactome in mouse brains, revealing its synaptic distribution and novel protein complexes.