Oussama El Far

Leucine-rich glioma inactivated 1 is a ganglioside-binding protein

The paper shows LGI1 binds gangliosides and may organize lipid platforms for ion channels, and its loss disrupts these platforms in mice.

Near equilibrium unbinding of streptavidin/biotin using single molecule acoustic force spectroscopy.

This study uses acoustic force spectroscopy to measure streptavidin-biotin bond dissociation rates near equilibrium, aligning with bulk measurements and expanding the dynamic range of single molecule force spectroscopy.

A hyperglycosylated form of Kv1.2 upregulated in LGI1 knockout mice

The paper identifies a hyperglycosylated and phosphorylated form of Kv1.2 upregulated in Lgi1-/- mice and reports changes in its interactome.

Membrane constraints reshape synaptotagmin recognition by botulinum neurotoxin B1

This study shows how membrane constraints affect synaptotagmin recognition by botulinum neurotoxin B1 through lipid-mediated interactions, revealing limitations in AI predictions of membrane-bound complexes.

Rescue of normal excitability in LGI1-deficient epileptic neurons

This study shows that expressing LGI1 in LGI1-deficient neurons restores normal excitability by restoring Kv1.1 channel density and function at the axon initial segment.

Molecular Basis of Kv1 Channel Downregulation and Its Epileptogenic Implications in Lgi1 Knock-out Mice

This study investigates Kv1 channel downregulation in LGI1 knock-out mice, showing it occurs in somatodendritic regions and is linked to increased neuronal bursting and changes in the Kv1 interactome.

Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1

The paper uses patient-derived autoantibodies to study LGI1 localization and interactome in mouse brains, revealing its synaptic distribution and novel protein complexes.

An epitope specific patient-derived LGI1-autoantibody enhances neuronal excitability by modulating the Kv1.1 channel.

This study shows that an epitope-specific LGI1-autoantibody modulates Kv1.1 channel function, increasing neuronal excitability and potentially contributing to epileptiform activity.