Christian Lévêque

The paper shows LGI1 binds gangliosides and may organize lipid platforms for ion channels, and its loss disrupts these platforms in mice.

This study uses acoustic force spectroscopy to measure streptavidin-biotin bond dissociation rates near equilibrium, aligning with bulk measurements and expanding the dynamic range of single molecule force spectroscopy.

The paper identifies a hyperglycosylated and phosphorylated form of Kv1.2 upregulated in Lgi1-/- mice and reports changes in its interactome.

This study investigates Kv1 channel downregulation in LGI1 knock-out mice, showing it occurs in somatodendritic regions and is linked to increased neuronal bursting and changes in the Kv1 interactome.

The paper uses patient-derived autoantibodies to study LGI1 localization and interactome in mouse brains, revealing its synaptic distribution and novel protein complexes.