Zhaowei Meng

The paper introduces ThermoTargetMiner, a database that identifies protein targets of lung cancer therapeutics using the PISA assay, revealing novel targets for 77% of tested compounds.

HOLSER improves proteome coverage and depth for structural analysis of protein-ligand interactions and conformational changes.

The paper improves target identification in chemical proteomics by using Fisher's method to aggregate peptide-level data instead of protein-level data.

The paper shows that stochastic resonance enhances detection of low-level peptide signals in single-cell proteomics using TMT and a carrier proteome.

The paper introduces KISSE, a statistical framework for species identification using bone collagen tandem mass spectrometry data, which provides species identification and probability estimates.

The paper introduces OPTI-PISA, a method that automates and reduces sample requirements for drug target identification, demonstrating its effectiveness in cell lysates with sub-microgram samples.

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

This study shows that ultralight Caenorhabditis elegans, grown on isotopically depleted bacteria, have shorter lifespans despite faster growth and maturation.

The paper investigates the link between isoaspartate (isoAsp) and Alzheimer's disease by analyzing isoAsp levels and related biomarkers in blood samples from AD patients and healthy controls.