Bohdana Sokolova

The paper introduces ThermoTargetMiner, a database that identifies protein targets of lung cancer therapeutics using the PISA assay, revealing novel targets for 77% of tested compounds.

HOLSER improves proteome coverage and depth for structural analysis of protein-ligand interactions and conformational changes.

The paper improves target identification in chemical proteomics by using Fisher's method to aggregate peptide-level data instead of protein-level data.

The paper introduces AFDIP, a chemical proteomics method that identifies drug target binding sites with high structural resolution using digestion rate analysis and MD simulations.

This study investigates trypsin cleavage preferences in native proteins using AFDIP, finding lysine cleavage is more abundant and faster than arginine in native conditions.