Xuepei Zhang

HOLSER improves proteome coverage and depth for structural analysis of protein-ligand interactions and conformational changes.

The paper improves target identification in chemical proteomics by using Fisher's method to aggregate peptide-level data instead of protein-level data.

This study demonstrates that Fourier Transform Isotopic Ratio Mass Spectrometry can reliably analyze isotope ratios from less than 10 ng of protein, enabling single-cell-scale stable isotope analysis.

The paper introduces GAPPIS, a method to recover molecular weight information from shotgun proteomics, identifying novel caspase 3 substrates in apoptotic cells.

This study shows that ultralight Caenorhabditis elegans, grown on isotopically depleted bacteria, have shorter lifespans despite faster growth and maturation.

This study introduces a gene essentiality signature to predict drug mechanisms of action and target interactions, showing improved accuracy over existing methods.