mRNA-Based Designer APCs Elicit Robust CD8⁺ and CD4⁺ T Cell Responses
Toan Van Le, Shota Imai, Iriya Fujitsuka, Makie Ueda, Sayuri Nakamae, Shusaku Mizukami, Rikinari Hanayama, Tomoyoshi Yamano
This paper develops an mRNA-based platform that reprograms somatic cells into designer APCs, enhancing T cell responses against tumors and demonstrating translational potential in human and mouse models.
bioRxiv · Sep 16, 2025 · PreprintImmunology