Sylvia Villeneuve

The paper investigates the association between CSF complement proteins and early AD pathology in at-risk individuals, finding C1q and Factor H linked to tau and synaptic markers.

The paper presents an open dataset of cerebral tau deposition in young healthy adults using [18F]MK6240 PET to support imaging biomarker studies in non-geriatric populations.

The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.

The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.

This study finds increased tau deposition in TLE patients using PET imaging, linked to cognitive impairment and brain connectivity patterns.

The paper examines how aging, Alzheimer's pathology, and APOE4 genotype affect longitudinal functional connectivity and episodic memory in older adults.

The paper examines sex-specific and APOE4-related associations between cardiometabolic risk factors and white matter microstructure in individuals with a family history of Alzheimer's disease.

The paper examines how precuneus activity during memory retrieval relates to future amyloid burden and cognitive outcomes in APOE4 carriers and non-carriers.

The paper identifies PTPRS as a neuroprotective marker in Alzheimer's disease, showing associations with reduced tau pathology and synaptic degeneration, particularly in males.

The paper investigates brain connectivity patterns associated with long-term smoking behavior change in older adults at risk for Alzheimer's disease.

The paper identifies joint signatures of microstructural and morphological changes in the Alzheimer's spectrum using MRI metrics and non-negative matrix factorization, linking them to risk factors and disease progression.

The paper examines the link between social isolation and Alzheimer's disease-related dementias risk using large population cohorts.

This study assesses white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease by analyzing signal measures from different MRI contrasts and their associations with clinical variables.

The paper examines how APOE ε2 and ε4 variants affect hippocampus-default network subregion co-variation, revealing sex-specific associations with lifestyle and health traits.

The paper investigates the relationship between white matter hyperintensities, amyloid, and pTau with cognitive decline in cognitively normal older adults, finding WMHs are linked to future executive functioning decline.

This study finds that higher cholesterol and diastolic blood pressure levels are linked to reduced brain functional connectivity over time in individuals at risk for Alzheimer's disease.

The paper examines associations between white matter microstructure and Aβ/tau pathology in specific brain bundles in at-risk older adults, finding diffusion metrics linked to Aβ and tau levels at cortical endpoints.

The paper develops a model to predict brain aging from resting state fMRI and finds accelerated brain aging in preclinical Alzheimer's disease, independent of amyloid-beta pathology.

The paper identifies distinct morphometric network changes in aging and Alzheimer’s disease, showing additive effects of aging and AD on GM loss, with unique whole-brain pattern variability in AD.

This study uses data-driven clustering to identify spatial patterns of tau-PET distribution in Alzheimer’s disease and compares them to pathology-driven ROIs, finding two clusters with strong cognitive associations.

The paper identifies subtypes of functional brain connectivity in older adults linked to Alzheimer's disease symptoms and risk factors.