Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R. McKnight, Thomas P. Keeley, Katelyn A. Bustin, Eric W. Barr, Snehil R. Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, HU Ren-ming, Kelly Hicks, Xie Wang, Donald M. O’Rourke, , Megan L. Matthews
This paper identifies hydralazine as an inhibitor of cysteamine dioxygenase (ADO), showing its role in treating preeclampsia and inducing senescence in glioblastoma.
Science Advances · Oct 15, 2025Peer-reviewedBiochemistry