Kyosuke Shishikura

This paper identifies hydralazine as an inhibitor of cysteamine dioxygenase (ADO), showing its role in treating preeclampsia and inducing senescence in glioblastoma.

The paper uses activity-based proteomics to identify Secernin-3 as a functional target involved in thermal nociception using phenelzine-based probes.

This study generates human fetal zone adrenal cortex-like cells from induced pluripotent stem cells, revealing key signaling pathways and transcription factors involved in adrenocortical specification and steroidogenesis.