Author

Nate R. McKnight

University of PennsylvaniaORCID 0000-0001-8573-1969Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Katelyn A. BustiniD· 2 shared Kyosuke ShishikuraiD· 2 shared Megan L. MatthewsiD· 2 shared Xie WangiD· 2 shared Zongtao LiniD· 2 shared Aimin LiuiD· 1 shared Alison JaccardiD· 1 shared Andrew F. Jarvis· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

Katelyn A. BustinORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 22, 2026

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation

Santanu Ghosh, Andrew F. Jarvis, Jordi C. J. Hintzen…·Donita C. Brady

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

1 citation

metabolomicsexperimental assay

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BiochemistryScience AdvancesPeer-reviewedOct 15, 2025

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma

Kyosuke Shishikura, Jiasong Li, Yiming Chen…·Megan L. Matthews

This paper identifies hydralazine as an inhibitor of cysteamine dioxygenase (ADO), showing its role in treating preeclampsia and inducing senescence in glioblastoma.

3 citations

humanmouse

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NeuroscienceMolecular and Cellular NeurosciencePeer-reviewedJun 1, 2023

Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception

Katelyn A. Bustin, Kyosuke Shishikura, Irene Chen…·Megan L. Matthews

The paper uses activity-based proteomics to identify Secernin-3 as a functional target involved in thermal nociception using phenelzine-based probes.

12 citations

mouseproteomics

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