Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma
Veveeyan Suresh, Christoph Hafemeister, Andri Konstantinou, Sarah Grissenberger, Caterina Sturtzel, Florencia Cidre‐Aranaz, Andrea Wenninger-Weinzierl, Martha Magdalena Zylka, Karla C. S. Queiroz, Dorota Kurek, Ana Sastre Urgellés, Javier Alonso, Martin Distel, Anna C. Obenauf, Thomas G. P. Grünewald, , Valerie Fock
This study models EWS::FLI1 fluctuations in Ewing sarcoma, showing that partial depletion promotes metastasis and identifies gene clusters and transcription factors linked to poor prognosis.
bioRxiv · Apr 3, 2025 · PreprintCancer Biology