Veveeyan Suresh

This paper introduces a 3D co-culture model of bone sarcoma metastasis in the lung and identifies a contact-dependent epithelial remodeling response with potential therapeutic targets.

This study models EWS::FLI1 fluctuations in Ewing sarcoma, showing that partial depletion promotes metastasis and identifies gene clusters and transcription factors linked to poor prognosis.

The paper shows that IGF-1 reprograms bone mesenchymal stem cells in EWS::FLI1-mutant mice, leading to tumor formation, with Yap1 playing a central role, and suggests combined IGF-1R and YAP/TEAD inhibition as a potential treatment.