Dorota Kurek

A Novel Human Distal Tubuloid-On-A-Chip Model For Investigating Sodium And Water Transport Mechanisms

This paper presents a human distal tubuloid-on-a-chip model to study sodium and water transport, showing enhanced distal markers, polarized epithelium, and functional sodium transport under flow conditions.

Modeling Hepatocellular Carcinoma and its microenvironment on a chip

This study evaluates drug responses in a patient-derived HCC chip model, showing varying effects on tumor cells and microenvironment factors like vasculature and cytokines.

Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma

This study models EWS::FLI1 fluctuations in Ewing sarcoma, showing that partial depletion promotes metastasis and identifies gene clusters and transcription factors linked to poor prognosis.

Validation of an MPS based intestinal cell culture model for the evaluation of drug-induced toxicity

This paper validates an MPS intestinal cell culture model for assessing drug-induced toxicity by comparing TEER measurements to 2D models and testing 23 compounds.

A microvascularized in vitro liver model for disease modeling and drug discovery

This paper develops a scalable in vitro liver model with microvascular components to study disease and drug responses, showing it can model steatosis and fibrosis.