Karla C. S. Queiroz

A scalable tumor-vasculature-on-chip for CAR T cell trafficking and efficacy studies

This paper describes a scalable tumor-vasculature-on-chip platform to study CAR T cell trafficking and efficacy in a 3D tumor microenvironment.

Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow

This paper presents a scalable 3D BBB model using human cells in a microfluidic platform, showing improved barrier function with co-culture of endothelial cells, astrocytes, and pericytes.

Modeling Hepatocellular Carcinoma and its microenvironment on a chip

This study evaluates drug responses in a patient-derived HCC chip model, showing varying effects on tumor cells and microenvironment factors like vasculature and cytokines.

Scalable Image-Based Quantification of Cell Permeability and Actin Remodeling: An Example in a Gut-on-Chip Platform

This paper introduces a scalable method using organ-on-chip technology and image analysis to quantify cell permeability and actin remodeling in response to toxic compounds.

Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma

This study models EWS::FLI1 fluctuations in Ewing sarcoma, showing that partial depletion promotes metastasis and identifies gene clusters and transcription factors linked to poor prognosis.

Breaking barriers: the fungal toxin candidalysin disrupts epithelial integrity and induces inflammation in a gut-on-chip model

This study investigates how the fungal toxin candidalysin disrupts epithelial integrity and induces inflammation using gut-on-chip models, showing decreased barrier function and inflammatory responses.