Author

Valerie Fock

St. Anna Children's Cancer Research InstituteORCID 0000-0002-7812-4340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Florian HalbritteriD· 2 shared Heinrich KovariD· 2 shared Veveeyan SureshiD· 2 shared Aleksandr BykoviD· 1 shared Ana Sastre UrgellésiD· 1 shared Andrea Wenninger-WeinzierliD· 1 shared Andri KonstantinouiD· 1 shared Anna C. ObenaufiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Florian HalbritterORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 3, 2025

Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcoma

Veveeyan Suresh, Christoph Hafemeister, Andri Konstantinou…·Valerie Fock

This study models EWS::FLI1 fluctuations in Ewing sarcoma, showing that partial depletion promotes metastasis and identifies gene clusters and transcription factors linked to poor prognosis.

3 citations

humanbulk RNA-seq

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Cancer BiologyCell ReportsPeer-reviewedMar 1, 2025

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells

Rahil Noorizadeh, Barbara Sax, Tahereh Javaheri…·Heinrich Kovar

The paper shows that IGF-1 reprograms bone mesenchymal stem cells in EWS::FLI1-mutant mice, leading to tumor formation, with Yap1 playing a central role, and suggests combined IGF-1R and YAP/TEAD inhibition as a potential treatment.

11 citations

mouseexperimental assay

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