Jens Georg

LIGR-Nue for the global mapping of the bacterial sRNA targetome in vivo

The paper introduces LIGR-Nue, a method to map bacterial sRNA targetomes, identifying sRNA functions in post-transcriptional regulation.

Functional decoding reveals a hidden regulatory layer of the Salmonella transcriptome during infection

The paper develops a functional screening strategy to identify regulatory RNA activities in Salmonella during macrophage infection, revealing stage-specific regulatory roles of non-canonical sRNAs.

An unprecedented small RNA-riboswitch interaction controls expression of a bifunctional pump that is essential for Staphylococcus aureus infection

The paper identifies a novel RNA-RNA interaction regulating the mntY gene in Staphylococcus aureus, essential for metal homeostasis and virulence.

A library-based approach allows systematic and rapid evaluation of seed region length and reveals design rules for synthetic bacterial small RNAs

The paper evaluates the impact of seed region length on synthetic bacterial small RNAs using a library-based approach and shows 12 nucleotides suffice for regulation with Hfq.

Integrative analysis of the salt stress response in cyanobacteria

This study integrates transcriptomic, proteomic, and metabolomic data from Synechocystis sp. PCC 6803 to characterize the salt stress response, identifying key regulatory elements and metabolic changes.

Global analysis of the RpaB regulon based on the positional distribution of HLR1 sequences and comparative differential RNA-Seq data

This paper identifies the RpaB regulon in Synechocystis sp. PCC 6803 by analyzing HLR1 motif positioning and RNA-Seq data, revealing 150+ regulated genes with activation or repression based on HLR1-TSS distance.

6S RNA supports recovery from nitrogen depletion in Synechocystis sp. PCC 6803

This study shows that 6S RNA in Synechocystis sp. PCC 6803 aids recovery from nitrogen depletion by regulating sigma factor switching and maintaining photosynthetic activity.