Sphingosine-1-phosphate signaling inhibition suppresses Th1-like Treg generation by reversing mitochondrial uncoupling
Rachel Coulombeau, Claudia Selck, Nicolas Giang, Abdulrahman Al-Mohammad, Natalie Ng, Allison K. Maher, Rafael José Argüello, Antonio Scalfari, James A. Varley, Richard S. Nicholas, Margarita Dominguez‐Villar
This study shows that inhibiting S1P signaling with FTY720 suppresses Th1-like Treg generation and restores their suppressive function by reversing mitochondrial uncoupling.
Immunology · Oct 24, 2024Peer-reviewedImmunology