William J. Tyler

Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model

This paper develops an exposure-response model to estimate cardiac safety margins for repeated low-dose psilocybin, finding a large safety margin due to psilocin's low-efficacy partial agonism and short half-life.

Transcranial focused ultrasound to rIFG improves response inhibition through modulation of the P300 onset latency

This study uses transcranial focused ultrasound on rIFG during a Stop-Signal task to show that it improves response inhibition by reducing P300 onset latency, not amplitude.

The Safety and Efficacy of Transdermal Auricular Vagal Nerve Stimulation Earbud Electrodes for Modulating Autonomic Arousal, Attention, Sensory Gating, and Cortical Brain Plasticity in Humans.

Transdermal electrical neuromodulation of the trigeminal sensory nuclear complex improves sleep quality and mood.

This study shows that transdermal electrical neuromodulation of trigeminal and cervical nerves improves sleep quality and mood in healthy individuals.

Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans

This study shows that transdermal neuromodulation of noradrenergic activity reduces stress responses in humans by suppressing sympathetic tone and biochemical markers of stress.