Suhas Sureshchandra

Human Th17 state classification reveals a selective vulnerability in acylcarnitine metabolism in type 2 diabetes

The paper classifies human Th17 cells into non-pathogenic and pathogenic states and identifies acylcarnitine metabolism as a vulnerability in type 2 diabetes.

A tonsil organoid model reveals Epstein-Barr virus infected germinal center B cell states during primary infection

This study develops an EBV-infected tonsil organoid model to study B cell states and antiviral responses during primary infection, revealing unique transcriptional programs and immune interactions.

Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibition

This study uses spatial transcriptomics to show that immune checkpoint inhibitors activate microglia via T cell interactions, leading to neuroinflammation and synaptic dysfunction in the brain.

Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood

This study examines age-related differences in T follicular helper cell function and their impact on antibody responses across human development.

Tissue determinants of the human T cell receptor repertoire.

This study analyzes T cell receptor repertoires in blood and tonsils, finding low clonal sharing and tissue-specific diversity, emphasizing the need for tissue-based analysis.

Exploratory extracellular vesicle-bound miRNA profiling to identify candidate biomarkers of chronic alcohol drinking in non-human primates

This study identifies EV-miRNA biomarkers associated with chronic alcohol drinking in non-human primates and links them to inflammatory responses.