Junpei Xiao

Defining the role of RNase E in the mycobacterial degradosome-like network

This study defines the interactions among mycobacterial mRNA degradation enzymes and identifies the functional roles of RNase E's intrinsically disordered regions in degradation processes.

GplR1, an unusual TetR-like transcription factor in Mycobacterium abscessus, controls the production of cell wall glycopeptidolipids, colony morphology, and virulence

This paper identifies GplR1, a transcription factor in Mycobacterium abscessus, as a regulator of glycopeptidolipid production, colony morphology, and virulence.

Mycobacterium tuberculosis MutT4 is an RNA pyrophosphohydrolase that forms biomolecular condensates and sensitizes mRNAs to degradation

This study identifies MutT4 in Mycobacterium tuberculosis as the RppH homolog, showing it forms condensates that facilitate mRNA degradation and enhance stress resistance.