Stefan H. Oehlers

This study shows that loss of DHCR7 leads to increased 7DHC, which activates IRF3 and impairs anti-bacterial immunity against Mycobacterium marinum in zebrafish.

This study identifies novel small molecules that prevent LPS-induced endotoxemia in zebrafish, showing that dabigatran protects through a thrombin-independent mechanism.

The paper shows that Mycobacterium abscessus grows preferentially in granulomas formed by prior Mycobacterium marinum infection in zebrafish, exploiting a nutrient-rich niche.

This paper identifies GplR1, a transcription factor in Mycobacterium abscessus, as a regulator of glycopeptidolipid production, colony morphology, and virulence.

The paper shows pyrimethamine, an FDA-approved drug, reduces vascular permeability and mycobacterial burden in a zebrafish infection model by inhibiting bacterial dihydrofolate reductase and restoring vascular barrier function.

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.

This study uses zebrafish models to investigate the role of lipid genes in fatty liver disease, finding that gene knockdowns enhance ethanol and high fat diet-induced liver damage.

This study investigates the role of zebrafish hmox1a and hmox1b in development and macrophage migration, finding that hmox1a has a conserved function similar to mammalian Heme oxygenase 1.