Author

Sagen E. Flowers

University of California, Santa BarbaraORCID 0000-0002-7818-2188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Research Focus:gene regulatory network inference· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Chee Kiang EweiD· 3 shared Joel H. RothmaniD· 3 shared Geneva AlokiD· 2 shared Yamila N. Torres CleureniD· 2 shared Erica M. SommermanniD· 1 shared Josh KencheliD· 1 shared Melissa R. AlcorniD· 1 shared Morris MaduroiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenetics

Chee Kiang EweORCID

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3 papers

Recent·Most cited

Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

Sagen E. Flowers, Rushali Kothari, Yamila N. Torres Cleuren, Melissa R. Alcorn, Chee Kiang Ewe, Geneva Alok, Samantha L Fiallo, Pradeep M. Joshi, Joel H. Rothman

This study shows that programmed cell death and aging pathways regulate mtDNA quality control and transmission in C. elegans by affecting the accumulation of a defective mtDNA mutation.

eLife · Sep 19, 2023Peer-reviewedGenetics

Feedforward regulatory logic underlies robustness of the specification-to-differentiation transition and fidelity of terminal cell fate during C. elegans endoderm development

Chee Kiang Ewe, Erica M. Sommermann, Josh Kenchel, Sagen E. Flowers, Morris Maduro, Joel H. Rothman

The paper identifies a feedforward regulatory logic in C. elegans endoderm development that ensures robustness and fidelity of cell fate specification and differentiation.

bioRxiv · Aug 24, 2021 · PreprintDevelopmental Biology

Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network

Chee Kiang Ewe, Yamila N. Torres Cleuren, Sagen E. Flowers, Geneva Alok, Russell G. Snell, Joel H. Rothman

The paper investigates how heritable epigenetic factors contribute to cryptic variation in the requirement for SKN-1 in endoderm development in C. elegans.

Proceedings of the National Academy of Sciences · Jun 1, 2020Peer-reviewedGenetics