Pradeep M. Joshi

This study shows that programmed cell death and aging pathways regulate mtDNA quality control and transmission in C. elegans by affecting the accumulation of a defective mtDNA mutation.

This study identifies ion channels and neurons essential for gravity sensing in C. elegans, showing distinct mechanisms from touch sensation and suggesting evolutionary homology with mammalian systems.

The paper introduces AMBER, a genetically encoded bioluminescent voltage indicator that does not require exogenous substrate, enabling voltage imaging in freely moving animals.

The paper shows C. elegans embryos adjust cell division timing in response to temperature gradients to maintain developmental fidelity.

This study shows that separase and caspases, though specialized in cell division and apoptosis, can partially substitute for each other in C. elegans, suggesting evolutionary co-option of cellular components.

The paper identifies cryptic variation in the C. elegans endoderm gene regulatory network, showing that some embryos can develop endoderm without key regulators, while others require them.