Thomas Stiehl

Aberrant DNA methylation is co-regulated across the genome in leukemia and other types of cancer

This study identifies co-regulated DNA methylation patterns in leukemia and shows their presence in other cancer types, suggesting non-random, network-based epigenetic regulation.

Molecular architecture of human dermal sleeping nociceptors

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age

The paper introduces a weighted 2D-kernel density estimation method for epigenetic age prediction, achieving similar accuracy to existing clocks and providing variation scores linked to mortality risk.

Cell-to-cell mobility of the stem cell inducing WUSCHEL transcription factor is controlled by a balance of transport and retention

The paper investigates WUSCHEL protein mobility in Arabidopsis thaliana shoot apical meristem, showing it is balanced between transport and retention, independent of CLAVATA3.

In vivo high-throughput screening of novel adeno-associated viral capsids targeting adult neural stem cells in the subventricular zone

The paper identifies AAV variants that efficiently target adult neural stem cells in the subventricular zone, enabling genetic modification for potential regenerative therapies.

Progressive changes in hippocampal stem cell properties ensure lifelong neurogenesis

The paper shows that hippocampal stem cells in mice undergo progressive behavioral changes that reduce depletion and ensure lifelong neurogenesis.

Mathematical modeling of plant cell fate transitions controlled by hormonal signals

The paper develops a mathematical model to study how hormonal signals influence cell fate transitions in plant shoot meristems, revealing the role of HECATE in stem cell differentiation.

New Targeted Approaches for Epigenetic Age Predictions

This study develops a new epigenetic age prediction model based on stochastic DNA methylation patterns observed in targeted CpG sites using BBA-seq.