Ryan Balfour Sartor

This study shows that dietary protein source affects colitis severity by altering gut bacteria and bile acid profiles, with beef protein causing more severe inflammation than pea protein.

The paper shows reduced GLP-1+ cell numbers in inflamed intestinal tissues of mice and CD patients, linked to an inflammatory metabolic signature affecting epithelial differentiation.

This study shows that TL1A overexpression in Crohn's Disease and mice causes Paneth cell dysfunction and microbiota changes that promote ileal inflammation.

This study develops a PSC-IBD mouse model and shows that dysbiotic microbiota and bile acid metabolism drive colitis and carcinogenesis.

This study shows that adapting human IBD microbiota for mice improves colonization efficiency and alters microbiome aggressiveness based on the recipient's inflammatory environment.

AuPhos enhances intestinal epithelial cell mitochondrial function, reduces mucosal oxygen delivery, and corrects dysbiosis and metabolic imbalances in IBD.

The paper identifies ten new genes with coding variants linked to Crohn's disease risk using sequencing data from over 30,000 patients and 80,000 controls.