Author

Manikandan Samidurai

University of GeorgiaORCID 0000-0002-7825-206XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Arthi KanthasamyiD· 2 shared Emir MaloviciD· 2 shared Gary D. ZenitskyiD· 2 shared Huajun JiniD· 2 shared Vellareddy AnantharamiD· 2 shared Adhithiya Charli· 1 shared Alyssa EalyiD· 1 shared Anil KumariD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Arthi KanthasamyORCID

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2 papers

Recent·Most cited

Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases

Adhithiya Charli, Jie Luo, Bharathi Palanisamy, Emir Malovic, Zainab Riaz, Cameron Miller, Yuan-Teng Chang, Manikandan Samidurai, Gary D. Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy

This study shows mitochondrial stress triggers PKCδ activation and Lamin B1 phosphorylation, leading to nuclear membrane damage and neuronal cell death in Parkinson's disease.

Frontiers in Cellular Neuroscience · Apr 17, 2025Peer-reviewedNeuroscience

KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease

Manikandan Samidurai, Karthick Chennakesavan, Souvarish Sarkar, Emir Malovic, Hai Minh Nguyen, Latika Singh, Anil Kumar, Alyssa Ealy, Chelva Janarthanam, Bharathi N. Palanisamy, Naveen Chandra Kondru, Gary D. Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G. Kanthasamy, , Arthi Kanthasamy

This study shows that inhibiting KCa3.1 channels reduces neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease models.

bioRxiv · Mar 18, 2025 · PreprintNeuroscience