Jie Luo

A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity

This paper identifies a druggable chromatin vulnerability in suppressive neutrophils that can restore antitumor immunity through mSWI/SNF antagonists.

Rewiring Oncogenic Transcriptional Complexes with Domain-ALTerAtion Chimeras (DALTACs) in Prostate Cancer

A bifunctional AR–p300/CBP molecule, DALTAC-1, forces a non-native contact between AR and p300 domains, silences AR enhancers and regresses AR-driven prostate tumors in mice while sparing AR-negative lines.

Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response

RTX-117, a clinical stage eIF2B activator, blunts chronic ISR activation and improves nerve and motor function in a mouse model of Charcot-Marie-Tooth Disease Type 2D.

LARP4 is a B cell-specific metabolic checkpoint for plasma cell differentiation and a therapeutic target in systemic lupus erythematosus

Modeling differences in neurodevelopmental maturity of the reading network using support vector regression on functional connectivity data

This paper uses support vector regression to model brain-age gaps in reading networks, finding that reading ability affects predicted brain maturity.

Exploring the mechanism of Panax Notoginseng in the treatment of skin wound based on network pharmacology and experimental verification

This study identifies the molecular mechanism of Panax Notoginseng in treating skin wounds using network pharmacology and experimental validation, revealing key targets and pathways involved in wound healing.

Leonardo: a toolset to correct sample-induced artifacts in light sheet microscopy images

Leonardo corrects sample-induced artifacts in light sheet microscopy images using two modules, validated on diverse biological samples.

Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases

This study shows mitochondrial stress triggers PKCδ activation and Lamin B1 phosphorylation, leading to nuclear membrane damage and neuronal cell death in Parkinson's disease.

CDP-DAG synthases regulate plant growth and broad-spectrum disease resistance

This study shows that CDP-DAG synthases in Arabidopsis regulate plant growth and disease resistance by modulating PA metabolism and immune signaling pathways.

Redefining the Game: MVAE-DFDPnet's Low-Dimensional Embeddings for Superior Drug-Protein Interaction Predictions

This paper introduces MVAE-DFDPnet, a deep learning model that generates low-dimensional embeddings for drug-protein interactions, achieving better performance than existing methods.