Souvarish Sarkar

Paraquat Inhalation Produces Male-Biased Dopaminergic Neuron Loss and Motor Deficits in Mice: Relevance to Parkinsons Disease

This study shows that prolonged low-dose inhalation of paraquat in mice causes male-specific dopaminergic neuron loss and motor deficits, linking it to Parkinson's disease.

Comparative Proteomic Analysis of Environmental and Genetic Models of Parkinsons Disease Highlights the Role of Purine Metabolism.

This study compares proteomic and metabolomic changes in genetic and environmental Parkinson's disease models, identifying purine metabolism as a shared pathway involved in neurotoxicity.

Brief report on differential toxicity of legacy and second-generation PFAS on dopaminergic neurons and mitochondria

This study compares the neurotoxicity and mitochondrial effects of legacy and second-generation PFAS using C. elegans and rat brain mitochondria, finding distinct mechanisms between the two classes.

Prokineticin-2 Upregulates GDNF in Astrocytes and Pharmacological Modulation of PK2 Receptors offers Neuroprotection in Experimental Models of Parkinson's Disease

This study shows that PK2 signaling increases GDNF in astrocytes and that modulating PK2 receptors protects neurons in Parkinson's disease models.

KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease

This study shows that inhibiting KCa3.1 channels reduces neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease models.

Epitranscriptomic Reader YTHDF2 Regulates SEK1(MAP2K4)-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress

This study shows YTHDF2 regulates inflammatory signaling in astrocytes during neurotoxic stress by modulating SEK1-JNK-cJUN pathway activation.

Genetic screening identifies glial adenosine as a therapeutic target in alpha-synucleinopathy

A Drosophila genetic screen identifies glial adenosine metabolism genes as therapeutic targets for alpha-synucleinopathies by improving locomotion and reducing neurodegeneration.

Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency

The paper identifies pathways controlling neurodegeneration and proteostasis in mitochondrial complex I deficiency using a Drosophila model and genetic screens.

Biotin rescues manganese-induced Parkinson's disease phenotypes and neurotoxicity

This study identifies biotin pathway dysregulation as a key mechanism linking manganese toxicity to Parkinson's disease using Drosophila and human iPSC models, showing biotin supplementation rescues neurotoxic phenotypes.