Luis Concha

This paper develops a framework to distinguish radial and tangential fiber components in human superficial white matter and examines their microstructural and functional properties.

This study examines thalamo-cortical and thalamo-hippocampal functional connectivity in temporal lobe epilepsy, finding reduced connectivity in TLE patients and its association with seizure generalization and surgical outcomes.

This study examines sex differences in structural brain alterations in common epilepsies using neuroimaging data from a large international cohort, finding some regional differences but no significant sex-by-diagnosis interactions.

This study quantifies cortical dislamination using electrical pattern analysis in an animal model and links it to neural dynamics and excitation-inhibition balance.

This study uses b-tensor encoding diffusion MRI in a murine model to assess microarchitectural changes in cortical dysplasias, finding reduced fractional anisotropy and dysorganized myelinated fibers in treated animals.

The paper identifies a reproducible functional connectivity signature in temporal lobe epilepsy through a large-scale connectome-wide analysis.

This study uses QSM to track brain iron accumulation in a pilocarpine-induced epilepsy model, finding increased iron deposits in specific brain regions over time.

This study identifies patient-specific functional biomarkers in temporal lobe epilepsy using multimodal MRI data to predict clinical outcomes and guide precision therapeutics.

This study evaluates white matter microstructure in asymmetric glaucoma using advanced diffusion MRI methods, finding significant diffusion metric differences and correlations with clinical parameters.

The paper examines associations between epilepsy-related polygenic risk scores and brain morphology in children, finding PRS-related cortical thinning linked to structural patterns in TLE-HS patients.

This study finds that cocaine use disorder is linked to reduced brain state transition energy in specific networks, particularly those involved in excitatory and higher-order functions.

The paper develops a computational framework to study superficial white matter organization using 3D histology and 7T MRI, finding high structural complexity in the first 2 mm below the cortical boundary and correlations with cortical geometry and connectivity.

This study identifies white matter structural correlates of predictive tapping synchronization in humans, linking fiber density and bundle properties to rhythmic entrainment abilities.

This study uses diffusion MRI to analyze microstructural changes in a rat model of cortical dysplasia across developmental stages, identifying abnormalities in fiber orientation and consistency with histology.

This study shows that pharmaco-resistant temporal lobe epilepsy causes a progressive shift in cortical excitation-inhibition balance, linked to cognitive impairments and seizure frequency.

This study identifies atypical functional topography and reduced hierarchical signal flow in temporal lobe epilepsy, linked to microstructural white matter changes and cognitive impairments.

This study shows that selectively lesioning GABAergic or cholinergic neurons in the medial septum of rats leads to behavioral changes and increased susceptibility to status epilepticus.

This study examines age-related changes in grey and white matter in TLE patients across the adult lifespan, finding accelerated aging effects after age 55.

This study uses b-tensor encoding and machine learning to classify histopathological damage in white matter, showing sensitivity to microstructural features.

The paper describes a pericapillary organ in the rat nervous system composed of tripartite synapses and astrocytic endfeet, suggesting a mechanoreceptor role and presynaptic modulation by Piezo 1 mRNA.

This study identifies atypical intrinsic neural timescales in temporal lobe epilepsy, showing reduced timescales in multiple brain regions and high accuracy in classifying patients and lateralizing seizure foci.

The paper identifies distinct functional and anatomical roles of motor cortex projections to the red nucleus and pons in mice, showing differential contributions to motor performance.

Micapipe is an open pipeline for processing multimodal MRI data, generating structural and functional connectomes, geodesic distances, and microstructural profiles across multiple brain parcellations and surface spaces.

This study identifies divergent patterns of atypical cortical asymmetry and regional atrophy in temporal lobe epilepsy using MRI data from a large multi-site cohort.

This study links structural network changes in epilepsy syndromes to risk gene expression patterns using ENIGMA data.

This study shows that astrocytic extracellular vesicles can accelerate spontaneous recovery after stroke in rats by promoting anatomical and functional recovery.

This study evaluates variability in white matter bundle segmentation across 42 groups using the same dataset, finding protocol variability exceeds other sources of inconsistency.

The paper identifies microglial activation as a factor contributing to cortical thinning in epilepsy by integrating neuroimaging and gene expression data.

The paper creates an MRI atlas of the juvenile axolotl brain, including ROIs, embryological divisions, and myelin regions, providing a resource for future research.

The paper investigates how timing skill training affects neural activity and performance in perceptual and motor timing tasks, finding heterogeneous responses and common neural changes in the timing network.