Author
Fabien Le Grand
Lyon 1 UniversitéORCID 0000-0002-7843-3899Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2016-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 15 mutual co-author links9 papers
Recent·Most cited
- Developmental BiologyDevelopmental CellPeer-reviewed
Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages that persist into adulthood.
Stamatia Gioftsidi, Takuto Hayashi, Sidy Fall…·Philippos Mourikis
This study shows that postnatal Pax7+ cells in limb muscles are multipotent, generating non-myogenic lineages like fibro-adipogenic progenitors that persist into adulthood and respond to injury.
1 citation - Developmental BiologyNature CommunicationsPeer-reviewed
Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells.
Gauthier Toulouse, William Jarassier, Sabrina Jagot…·Christophe Marcelle
The paper tracks progenitor populations in avian embryos to reveal distinct lineages of primary and secondary myotubes and their relationship to adult muscle stem cells.
2 citations - PhysiologyEMBO ReportsPeer-reviewed
Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P
Dieu-Huong Hoang, Jessica Bouvière, Johanna Galvis…·Bénédicte Chazaud
This study identifies that immune aging impairs muscle regeneration by altering macrophage-derived antioxidant selenoprotein P expression and function in aged mice.
20 citationstop 4% - Cell BiologybioRxivPreprint
Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells
Erik Jacques, Pauline Garcia, Orane Mercier…·Fabien Le Grand
The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.
- BioengineeringAdvanced Materials InterfacesPeer-reviewed
A cryopreservation strategy for myoblast storage in paper-based scaffolds for inter-laboratory studies of skeletal muscle health
Saifedine T. Rjaibi, Erik Jacques, Jiaru Ni…·Alison P. McGuigan
This paper develops a cryopreservation method for myoblasts in paper-based scaffolds, enabling inter-laboratory studies of skeletal muscle health.
2 citations - Developmental BiologyNucleic Acids ResearchPeer-reviewed
LSD1 controls a nuclear checkpoint in Wnt/β-catenin signaling to regulate muscle stem cell self renewal
Sandrine Mouradian, Delia Cicciarello, Nicolas Lacoste…·Isabella Scionti
This study identifies LSD1 as a regulator of Wnt/β-catenin signaling by demethylating β-catenin to prevent its degradation, thereby influencing muscle stem cell self-renewal.
22 citations - Developmental Biologynpj Regenerative MedicinePeer-reviewed
Odd skipped-related 1 controls the pro-regenerative response of Fibro-Adipogenic Progenitors
Georgios Kotsaris, Taimoor H. Qazi, Christian H. Bucher…·Sigmar Stricker
This study identifies Osr1 as essential for FAPs to support muscle regeneration by regulating communication with MuSCs and macrophages, and its loss leads to impaired regeneration and fibrosis.
31 citations - Cell BiologybioRxivPreprint
R-spondin1 regulates muscle progenitor cell fusion through control of antagonist Wnt signaling pathways
Floriane Lacour, Elsa Vezin, Florian Bentzinger…·Fabien Le Grand
This study shows Rspo1 regulates muscle progenitor cell fusion by modulating canonical and non-canonical Wnt signaling pathways during muscle regeneration.
DOI 10.1101/063669