Christophe Marcelle

A Cre-responsive reporter quail for flexible genetic lineage tracing

This paper develops a Cre-responsive transgenic quail line for flexible genetic lineage tracing, enabling permanent labelling of embryonic cell populations through Cre-mediated recombination.

Curvature-guided chiral collective organization of myoblast tissues

This study shows curvature guides chiral organization and myogenic differentiation in myoblast tissues, with handedness determined by substrate curvature.

Extracellular matrix mediated stresses spatially bias myoblast fusion and myotube growth

The paper shows how extracellular matrix stresses spatially bias myoblast fusion and myotube growth through nematic organization and mechanical feedback.

Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells.

The paper tracks progenitor populations in avian embryos to reveal distinct lineages of primary and secondary myotubes and their relationship to adult muscle stem cells.

TopFlash transgenic quail reveals dynamic TCF/beta-catenin signaling during avian embryonic development

The paper develops transgenic quail lines with destabilized GFP reporters to dynamically monitor TCF/beta-catenin signaling during avian embryonic development.

Generation of transgenic quails by in vivo transfection of primordial germ cells

This paper generates transgenic quails using plasmid-based in vivo transfection of primordial germ cells, overcoming limitations of previous viral methods.

Auto-inhibition of myoblast fusion by cyclic receptor signalling.

This study identifies TGFβ signaling as a regulatory brake on myoblast fusion, showing that its cyclic activation controls the rate of muscle fusion during embryonic development.

AKT, NOTCH and GSK3β interact to trigger early myogenesis in vertebrate embryos.

The paper investigates how NOTCH1 exerts non-canonical functions in myogenesis by interacting with AKT and GSK3β in vertebrate embryos.