Cynthia A. Berlinicke

Identification a Compact Promoter using a New Promoter Selection Strategy and Engineering Hybrid Pol II/III Enable Efficient Genome Editing in Human Retinal Ganglion Cells

The paper identifies a compact Pol II promoter and hybrid Pol II/III promoters to enable efficient single-AAV delivery of SpCas9 for genome editing in human retinal ganglion cells.

Identification and functional characterization of an AMD associated c-ABL binding SNP streak within the ARMS2 gene promoter region

The paper identifies a 5-SNP block in the ARMS2 promoter that binds c-ABL and is associated with AMD, showing reduced transcriptional activity in reporter assays.

High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

The paper identifies novel pathways that enhance oligodendrocyte maturation and myelination through high-throughput screening of 2500 compounds using engineered human stem cell-derived OPCs.

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

Programmed Switch in The Mitochondrial Degradation Pathways During Human Retinal Ganglion Cell Differentiation from Stem Cells is Critical for RGC Survival

The paper shows that during human retinal ganglion cell differentiation, the mitochondrial degradation pathway shifts from the ubiquitine-proteasome system to the endo-lysosomal pathway, which is critical for cell survival.

Axon Guidance Signaling Modulates Epithelial to Mesenchymal Transition in Stem Cell-Derived Retinal Pigment Epithelium

This study investigates EMT in stem cell-derived RPE cells, identifying dysregulated axon guidance molecules during the process.