Arupratan Das

This study shows that WAY-100635, a 5-HT1A antagonist, reduces chronic neurodegeneration and immune activation after TBI by preserving neurons, synapses, and visual function.

This study identifies WAY-100635 as a neuroprotectant that reprograms metabolism to promote RGC differentiation and regeneration in glaucoma models.

The paper identifies that enhancing mitochondrial biogenesis through TBK1 inhibition protects glaucomatous retinal ganglion cells from mitochondrial damage.

The paper shows that during human retinal ganglion cell differentiation, the mitochondrial degradation pathway shifts from the ubiquitine-proteasome system to the endo-lysosomal pathway, which is critical for cell survival.