Joan Wong

The paper tracks antibiotic resistance gene (ARG) dynamics in mice during long-term antibiotic treatment, finding that commensal bacteria reduce ARG burden by outcompeting resistant taxa.

protoSpaceJAM automates and optimizes CRISPR/Cas9 gRNA and HDR donor design, improving knock-in efficiency through recoding mutations and customizable parameters.

PoMeLo predicts metabolic loss in pathogen genomes by analyzing gene and pathway degradation across bacterial species.

This paper uses evolutionary genomics to identify host metabolic pathways critical for intracellular bacterial survival, validating them through in vitro assays and metabolomics.