Author

James B. Bower

Indiana University BloomingtonORCID 0000-0002-7854-4927Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Joshua J. ZiarekiD· 2 shared Fabian BumbakiD· 1 shared Karen P Gomez· 1 shared Mingzhe PaniD· 1 shared Nagarajan VaidehiiD· 1 shared Scott A. RobsoniD· 1 shared Wijnand J. C. van der VeldeniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Joshua J. ZiarekORCID

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2 papers

Recent·Most cited

BiophysicsProtein SciencePeer-reviewedJan 23, 2026

Stabilization versus flexibility: detergent-dependent trade-offs in neurotensin receptor 1 GPCR ensembles

James B. Bower, Wijnand J. C. van der Velden, Karen P Gomez…·Joshua J. Ziarek

This study investigates how different detergents affect the stability and ligand binding of neurotensin receptor 1, revealing a trade-off between structural stabilization and conformational flexibility.

1 citation

protein structureexperimental assay

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BiophysicsbioRxivPreprintJan 31, 2024

Insights on the GPCR helix 8 solution structure and orientation using a neurotensin receptor 1 peptide

James B. Bower, Scott A. Robson, Joshua J. Ziarek

This study investigates the structural stability and orientation of the neurotensin receptor 1 H8-Ctail using NMR in detergent and lipid environments, revealing its sensitivity to membrane conditions.

DOI 10.1101/2024.01.31.578299

humanprotein structure

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