Author

Fabian Bumbak

Monash UniversityORCID 0000-0003-2739-8197Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:protein structure· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Joshua J. ZiarekiD· 3 shared Nagarajan VaidehiiD· 2 shared Wijnand J. C. van der VeldeniD· 2 shared Abinayah JohniD· 1 shared Anna KolesnikiD· 1 shared Christina Ringmann FagerbergiD· 1 shared Daniel J. ScottiD· 1 shared Elise Ng‐CordelliD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

Joshua J. ZiarekORCID

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3 papers

Recent·Most cited

BiophysicsProtein SciencePeer-reviewedJan 23, 2026

Stabilization versus flexibility: detergent-dependent trade-offs in neurotensin receptor 1 GPCR ensembles

James B. Bower, Wijnand J. C. van der Velden, Karen P Gomez…·Joshua J. Ziarek

This study investigates how different detergents affect the stability and ligand binding of neurotensin receptor 1, revealing a trade-off between structural stabilization and conformational flexibility.

1 citation

protein structureexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJan 21, 2026

Mapping the Ligand-dependent Remodeling of the Conformational Entropy Landscape in Neurotensin Receptor 1 by NMR-guided Molecular Simulations

Scott A. Robson, Fabian Bumbak, S. Bhattacharya…·Joshua J. Ziarek

This study uses NMR and MD simulations to analyze conformational entropy changes in GPCRs, showing how dynamic fluctuations influence allosteric signaling and receptor function.

1 citation

protein structurestatistical model

𝕏 PostBluesky

Genetic & Genomic MedicineGenetics in MedicinePeer-reviewedJan 28, 2022

Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder

Holly Melland, Fabian Bumbak, Anna Kolesnik…·Kate Baker

This study expands the known genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder by analyzing 22 individuals with de novo missense variants.

46 citationstop 3%

humanstatistical model

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