Mingzhe Pan

This study shows that inhibiting MAGL in astrocytes reduces seizures and neuroinflammation by activating CB1-PPAR-γ signaling, preserving synaptic function and preventing cognitive decline in epilepsy.

This study identifies two distinct conformational equilibria in arrestin-2 that underlie its pre-activation state in solution.

This study investigates how different detergents affect the stability and ligand binding of neurotensin receptor 1, revealing a trade-off between structural stabilization and conformational flexibility.

This study identifies astrocytic monoacylglycerol lipase (MAGL) as a therapeutic target for Alzheimer's disease, showing that its inactivation reduces pathology and improves cognition in transgenic mice.