Author

Hongjie Chen

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

Click to filter author papers

Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Antoine ChailloniD· 2 shared David M. MargolisiD· 2 shared Guochun JiangiD· 2 shared Yuyang Tang· 2 shared Ciniso Sylvester ShabanguiD· 1 shared Edward P. BrowneiD· 1 shared Jacob B Lovins· 1 shared Manickam AshokkumariD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Antoine ChaillonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A naturally occurring Tat R52W variant in brain-derived HIV attenuates transcription and may contribute to reservoir persistence

Hongjie Chen, Nan Jiang, Yuyang Tang, Antoine Chaillon, Sara Gianella Weibel, David M. Margolis, Venkat R. Chirasani, Guochun Jiang

This study identifies an HIV-1 Tat variant (R52W) that reduces transcriptional activity, potentially contributing to viral persistence during ART.

bioRxiv · Sep 23, 2026 · PreprintMicrobiology

SPP1+ Microglia Are Associated with Neuroimmune Rewiring and Glutamatergic Neuronal Injury in ART-Suppressed People Living with HIV

Ciniso Sylvester Shabangu, Hongjie Chen, Manickam Ashokkumar, Nikesh Katuwal, Jacob B Lovins, Edward P. Browne, Sara Gianella, Antoine Chaillon, David M. Margolis, Yuyang Tang, Guochun Jiang

In ART-suppressed human brain, an SPP1+ activated microglial subset holds most detected HIV RNA and shows chronic interferon-I and MHC-I signatures, alongside complement signaling and neuronal loss.

bioRxiv · Sep 10, 2026 · PreprintNeuroscience✦ In-depth digest