Author

Xumin Guan

Washington University in St. LouisORCID 0000-0002-7884-0849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Abhinav DiwaniD· 2 shared Attila Kovacs· 2 shared David R. RawnsleyiD· 2 shared Honora Navid· 2 shared Jess NigroiD· 2 shared John T. MurphyiD· 2 shared Moydul IslamiD· 2 shared Xiucui MaiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersMolecular Biology

Abhinav DiwanORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 3, 2026

Impaired proteostasis is an early feature of the diabetic heart in humans and mice

David R. Rawnsley, Chen Zhao, Xiucui Ma…·Abhinav Diwan

This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.

DOI 10.64898/2026.09.01.748593

mousehuman

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Cell BiologyCirculation ResearchPeer-reviewedAug 26, 2026

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

David R. Rawnsley, Moydul Islam, Chen Zhao…·Abhinav Diwan

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

4 citationstop 2%

mouseproteomics

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