John T. Murphy

Tryptophan Restores Recovery Competence Following Starvation in the Absence of Lysosomal Amino Acid Sensing

This study shows that tryptophan restores recovery competence after starvation in C. elegans by countering unrestrained mTOR activity, independent of lysosomal amino acid sensing.

Impaired proteostasis is an early feature of the diabetic heart in humans and mice

This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

Zinc excess promotes lysosome remodeling by activating HLH-30/TFEB through the action of the high zinc sensor HIZR-1.

The paper identifies a zinc-regulated genetic pathway in C. elegans that activates lysosome remodeling through HIZR-1 and HLH-30/TFEB to enhance zinc detoxification.

Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling.

This study shows that phosphorylation of CRYAB leads to condensate formation and worsens heart failure after myocardial infarction.