David R. Rawnsley

This study shows that tryptophan restores recovery competence after starvation in C. elegans by countering unrestrained mTOR activity, independent of lysosomal amino acid sensing.

This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

This study shows that phosphorylation of CRYAB leads to condensate formation and worsens heart failure after myocardial infarction.