Impaired proteostasis is an early feature of the diabetic heart in humans and mice
David R. Rawnsley, Chen Zhao, Xiucui Ma, Moydul Islam, John T. Murphy, Xumin Guan, Layla Foroughi, Attila Kovacs, Jess Nigro, Ziang Bi, Walter Navid, Honora Navid, Babak Razani, Daniel Scherr, Kartik Mani, , Abhinav Diwan
This study shows that impaired proteostasis is an early feature of diabetic cardiomyopathy in humans and mice, with intermittent fasting offering protective effects.
bioRxiv · Sep 3, 2026 · PreprintMolecular Biology