Helen R. Mott

Kinase interplay centered on two regulatory elements compartmentalizes the checkpoint protein Lte1 in S. cerevisiae

The paper identifies two regulatory elements in Lte1 that coordinate kinase activity to compartmentalize Lte1 at the bud cortex in S. cerevisiae, ensuring proper mitotic exit.

Structural basis of the protein kinase PKN1 HR1 domain oligomerization and differential regulation by RhoA and Rac1

This study investigates the structural roles of PKN1 HR1 domains in oligomerization and their differential regulation by RhoA and Rac1.

Assembly of novel, nuclear dimers of the PI3-Kinase regulatory subunits underpins the pro-proliferative activity of the Cdc42-activated tyrosine kinase, ACK

The paper shows ACK promotes cell proliferation by stabilizing p85 regulatory subunits and forming nuclear dimers, which may contribute to oncogenesis through novel PI3-Kinase regulation.